Palladia Tabs 15 mg

Palladia (Toceranib Phosphate) Tablets for Dogs

Palladia is an FDA-approved prescription veterinary medication containing toceranib phosphate, a targeted multi-kinase inhibitor specifically developed for dogs. It is indicated for the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors (MCTs) with or without regional lymph node involvement.

Key Features

• Targeted Cancer Therapy: Blocks tyrosine kinase receptors (including KIT, VEGFR, and PDGFR) that drive tumor cell growth and new blood vessel formation (angiogenesis).
• Convenient Oral Tablets: Available in 10 mg (blue), 15 mg (orange), and 50 mg (red) film-coated tablets for easy at-home administration.
• Proven Efficacy: Helps slow tumor growth, stabilize disease, or shrink tumors in many dogs with mast cell tumors.
• For Dogs Only: Specifically formulated and approved for canine use under veterinary supervision.

How Palladia Works

Unlike traditional chemotherapy that attacks all rapidly dividing cells, Palladia is a targeted therapy. It inhibits signaling pathways that cancer cells rely on for proliferation and survival while also cutting off the tumor’s blood supply. This dual action can limit tumor growth and reduce the risk of metastasis.

Indications

Palladia is approved for:

• Patnaik grade II (intermediate) or grade III (high-grade) recurrent cutaneous mast cell tumors
• Tumors that may or may not involve regional lymph nodes
• Cases where surgery is not possible or the tumor has recurred

Veterinary oncologists may also use it off-label for other cancers such as certain sarcomas, carcinomas, anal sac adenocarcinoma, and more, based on clinical judgment.

Dosage & Administration

The recommended initial dose is 3.25 mg/kg body weight administered orally every other day. Your veterinarian will calculate the exact number of tablets based on your dog’s weight and may adjust the dose (down to a minimum of 2.2 mg/kg) or temporarily interrupt treatment to manage side effects.

• Can be given with or without food (giving with food may reduce digestive upset).
• Do not split, crush, or break tablets unless directed.
• Always follow your veterinarian’s exact instructions and monitoring schedule.

Important Safety Information

Handle with care: Palladia is an anti-cancer medication. Wear gloves when handling tablets, especially broken ones. Wash hands thoroughly after administration. Pregnant women, nursing women, and children should avoid handling this medication. Store securely out of reach of children and pets.

Possible Side Effects

The most common side effects include:

• Diarrhea or soft stools
• Decreased appetite or anorexia
• Vomiting
• Lethargy
• Weight loss
• Lameness or musculoskeletal issues
• Blood in stool or gastrointestinal bleeding

Regular veterinary check-ups, including bloodwork, are essential during treatment to monitor for adverse reactions and adjust therapy as needed.

Why Choose Palladia?

Palladia offers a targeted, oral treatment option that can be administered at home, reducing the need for frequent clinic visits associated with traditional chemotherapy. When used under close veterinary supervision, it provides an important tool in managing mast cell tumors and improving quality of life for many dogs.

Prescription required. Always use as directed by a licensed veterinarian. This product is for animal use only.