Librela 15mg

Librela 15mg Solution for Injection for Dogs – Advanced Monthly Pain Relief for Osteoarthritis

Librela (bedinvetmab) is a groundbreaking veterinary monoclonal antibody therapy specifically designed to control pain associated with osteoarthritis (OA) in dogs. This innovative biological treatment targets Nerve Growth Factor (NGF), a key mediator of chronic joint pain, providing effective, long-lasting relief with a convenient once-monthly subcutaneous injection administered by a veterinarian.

Unlike traditional NSAIDs or oral pain medications, Librela offers a novel mechanism of action that helps improve mobility, activity levels, and overall quality of life for dogs suffering from degenerative joint disease. The 15mg strength is ideal for dogs weighing 20.1–30 kg (approximately 44–66 lbs).

Key Features & Benefits

• Once-Monthly Administration – Convenient subcutaneous injection every 28 days maintains consistent pain control.
• Targeted Action – Bedinvetmab, a caninised monoclonal antibody, selectively binds to and neutralises Nerve Growth Factor (NGF), blocking pain signal transmission to the brain.
• Improved Mobility & Quality of Life – Clinical studies show reduced pain, increased activity, and better overall well-being in dogs with OA.
• Veterinary Prescription Only (POM-V) – Ensures safe, professional diagnosis, dosing, and monitoring.
• Sterile Single-Use Vials – Each 1 ml vial contains 15 mg bedinvetmab in a clear to slightly opalescent solution.
• Compatible with Many Concurrent Therapies – Generally compatible with vaccines and parasiticides (always consult your vet).

How Librela Works

In dogs with osteoarthritis, cartilage breakdown leads to inflammation and elevated levels of Nerve Growth Factor (NGF). NGF amplifies pain signals. Bedinvetmab, the active ingredient in Librela, is a fully canine monoclonal antibody that binds specifically to NGF, preventing it from activating its receptors (TrkA). This reduces pain signalling without the typical side effects associated with long-term NSAID use in many patients.

Indications

Librela is indicated for the alleviation and control of pain associated with osteoarthritis in dogs aged 12 months and older.

Dosage & Administration

Administer by subcutaneous injection once monthly. The recommended dose is 0.5–1.0 mg/kg body weight.

For the 15 mg strength: Suitable for dogs weighing 20.1–30 kg. Administer the entire contents of one 1 ml vial.

Important: This product must be administered by a veterinary professional. It is not intended for home administration. Effectiveness may improve after the second dose. Always follow your veterinarian’s exact dosing and monitoring instructions.

Composition (per 1 ml vial)

• Active substance: Bedinvetmab 15 mg (canine monoclonal antibody expressed in Chinese hamster ovary cells)
• Excipients: L-histidine, histidine hydrochloride monohydrate, trehalose dihydrate, disodium edetate, L-methionine, poloxamer 188, water for injections

Storage

Store in a refrigerator at 2–8°C. Protect from light. Do not freeze. Use the entire contents of the vial immediately after puncture (no preservative). Keep out of reach of children.

Contraindications & Precautions

• Do not use in dogs under 12 months of age.
• Do not use in breeding, pregnant, or lactating dogs.
• Do not use in cases of known hypersensitivity to bedinvetmab or any excipient.
• Women who are pregnant, trying to conceive, or breastfeeding should take extreme care to avoid accidental self-injection.

Possible Side Effects

The most commonly reported adverse events in clinical studies include urinary tract infection, bacterial skin infection, dermatitis/skin inflammation, and mild injection site reactions (e.g., swelling or heat). Always discuss potential risks with your veterinarian and report any unusual symptoms promptly.

Why Choose Librela?

Librela represents a new era in canine osteoarthritis management. As the first anti-NGF monoclonal antibody approved for dogs, it provides targeted, monthly pain control that can significantly enhance your dog’s comfort, mobility, and joy of life. Available as a pack of 2 vials for convenient ongoing treatment under veterinary supervision.

Prescription required. This is a POM-V medicine and can only be dispensed against a valid prescription from a registered veterinary surgeon.