Zoetis Apoquel 5.4 mg – Fast, Targeted Relief from Allergic Itch in Dogs
Apoquel (oclacitinib) is a revolutionary non-steroidal medication specifically developed by Zoetis to control pruritus (itching) associated with allergic dermatitis and the clinical signs of atopic dermatitis in dogs 12 months of age and older. Unlike traditional steroids or antihistamines, Apoquel works at the source of the itch by selectively inhibiting Janus kinase (JAK) enzymes that drive the production of cytokines responsible for itching and inflammation.
Key Benefits
- Rapid onset of action – noticeable relief from itching can begin in as little as 4 hours
- Effective for flea allergy, food allergy, contact allergy, and atopic dermatitis
- Non-steroidal – avoids many of the common side effects associated with long-term corticosteroid use
- Minimal impact on the overall immune system compared to broader immunosuppressants
- Can be used for both short-term flare control and long-term maintenance therapy
- Can be discontinued without tapering
- Scored tablets for flexible dosing
How Apoquel Works
Oclacitinib is a selective Janus kinase (JAK1) inhibitor. It targets the specific cytokines (including IL-31) that signal the itch sensation and drive inflammation in allergic skin disease, providing targeted relief while largely sparing other immune pathways.
Active Ingredient
Each film-coated tablet contains 5.4 mg oclacitinib (as oclacitinib maleate).
Indications
Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Dosage & Administration
The recommended dose is 0.4 to 0.6 mg oclacitinib/kg body weight (0.18 to 0.27 mg/lb).
- Initial therapy: Administer twice daily (BID) for up to 14 days
- Maintenance therapy: Administer once daily (SID) at the same dose
- May be given with or without food
- Tablets are scored and can be divided into equal halves for accurate dosing
Important Safety Information
- For oral use in dogs only
- Not for use in dogs less than 12 months of age
- Not for use in dogs with serious infections
- May increase susceptibility to infection, including demodicosis, and may exacerbate neoplastic conditions
- Not for use in breeding, pregnant, or lactating dogs
- Prescription only – use only under the direction of a licensed veterinarian
Why Choose Apoquel?
Apoquel has been prescribed for millions of dogs worldwide and is highly rated by both veterinarians and pet owners for controlling allergic itch. It offers a modern alternative to steroids, delivering fast, effective, and targeted relief so your dog can get back to a comfortable, happy life.
Always consult your veterinarian before starting or changing any medication regimen for your pet.